Blar i Bergen Open Research Archive på forfatter "Akkouh, Ibrahim Ahmed"

Viser treff 1-8 av 8

    • Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort 

      Krull, Florian; Akkouh, Ibrahim Ahmed; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia; Smeland, Olav Bjerkehagen; O'Connell, Kevin Sean; Brattbakk, Hans-Richard; Steen, Vidar Martin; Steen, Nils Eiel; Djurovic, Srdjan; Andreassen, Ole (Journal article; Peer reviewed, 2022)
      Lithium is the first-line treatment for bipolar disorder (BD), but there is a large variation in response rate and adverse effects. Although the molecular effects of lithium have been studied extensively, the specific ...

    • Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders 

      Aas, Monica; Andreassen, Ole; Gjerstad, Johannes; Rødevand, Linn; Hjell, Gabriela; Johansen, Ingrid Torp; Lunding, Synve Hoffart; Ormerod, Monica Bettina E. Greenwood; Lagerberg, Trine Vik; Steen, Nils Eiel; Djurovic, Srdjan; Akkouh, Ibrahim Ahmed (Journal article; Peer reviewed, 2023)
      Exposure to early life trauma increases the risk of psychopathology later in life. Here we investigated if ANK3 mRNA levels influence the relationship between childhood trauma experiences and clinical characteristics in ...

    • A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia 

      Szabo, Attila; Akkouh, Ibrahim Ahmed; Vandenberghe, Matthieu; Osete, Jordi Requena; Hughes, Timothy; Heine, Vivi M.; Smeland, Olav Bjerkehagen; Glover, Joel Clinton; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)
      While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent ...

    • Longitudinal Transcriptomic Analysis of Human Cortical Spheroids Identifies Axonal Dysregulation in the Prenatal Brain as a Mediator of Genetic Risk for Schizophrenia 

      Akkouh, Ibrahim Ahmed; Ueland, Thor; Szabo, Attila; Hughes, Timothy; Smeland, Olav Bjerkehagen; Andreassen, Ole; Requena Osete, Jordi; Djurovic, Srdjan (Journal article; Peer reviewed, 2024)
      Background Schizophrenia (SCZ) has a known neurodevelopmental etiology, but limited access to human prenatal brain tissue hampers the investigation of basic disease mechanisms in early brain development. Here, we elucidate ...

    • Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway 

      Wang, Shan; Rhijn, Jon-Ruben van; Akkouh, Ibrahim Ahmed; Kogo, Naoki; Maas, Nadine; Bleeck, Anna; Ortiz, Irene Santisteban; Lewerissa, Elly; Wu, Ka Man; Schoenmaker, Chantal; Djurovic, Srdjan; van Bokhoven, Hans; Kleefstra, Tjitske; Nadif Kasri, Nael; Schubert, Dirk (Journal article; Peer reviewed, 2022)
      Heterozygous loss-of-function (LoF) mutations in SETD1A, which encodes a subunit of histone H3 lysine 4 methyltransferase, cause a neurodevelopmental syndrome and increase the risk for schizophrenia. Using CRISPR-Cas9, we ...

    • Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia 

      O'Connell, Kevin Sean; Koch, Elise; Lenk, Hasan Cagin; Akkouh, Ibrahim Ahmed; Hindley, Guy Frederick Lanyon; Jaholkowski, Piotr Pawel; Smith, Robert Løvsletten; Holen, Børge; Shadrin, Alexey; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Steen, Nils Eiel; Dale, Anders M; Molden, Espen; Djurovic, Srdjan; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Treatment resistant schizophrenia (TRS) is characterized by repeated treatment failure with antipsychotics. A recent genome-wide association study (GWAS) of TRS showed a polygenic architecture, but no significant loci were ...

    • Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation 

      Sheikh, Mashhood Ahmed; O'Connell, Kevin Sean; Lekva, Tove; Szabo, Attila; Akkouh, Ibrahim Ahmed; Osete, Jordi Requena; Agartz, Ingrid; Engh, John; Andreou, Dimitrios; Boye, Birgitte; Bøen, Erlend; Elvsåshagen, Torbjørn; Hope, Sigrun; Werner, Maren Caroline Frogner; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Melle, Ingrid; Drange, Ole Kristian; Morken, Gunnar; Nærland, Terje; Sørensen, Kjetil; Vaaler, Arne; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Aukrust, Pål; Djurovic, Srdjan; Steen, Nils Eiel; Andreassen, Ole; Ueland, Thor (Journal article; Peer reviewed, 2022)
      Background: Cell adhesion molecules (CAMs) orchestrate leukocyte trafficking and could link peripheral and neuroinflammation in patients with severe mental illness (SMI), by promoting inflammatory and immune-mediated ...

    • Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids 

      Osete, Jordi Requena; Akkouh, Ibrahim Ahmed; Levglevskyi, Oleksandr; Vandenberghe, Matthieu; Reis de Assis, Denis; Ueland, Thor; Kondratskaya, Elena; Holen, Børge; Szabo, Attila; Hughes, Timothy; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2023)
      Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived brain organoids have emerged as a ...